NEW EMBO MEMBER'S REVIEW: T-cell factors: turn-ons and turn-offs

Chromatin turn ons and turn offs of ribosomal RNA genes.

Eukaryotes have hundreds (sometimes thousands) of ribosomal RNA (rRNA) genes whose transcription by RNA polymerase I helps establish the proliferative ability of cells by dictating the pace of ribosome production and protein synthesis. Interestingly, only a subset of the total rRNA gene pool is active at any one time, making rRNA genes attractive for understanding the dynamic balance between ge...

Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells

Lymphocytes of the gamma delta (γδ) T-cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors, a large proportion respond as innate effectors. γδ T-cells are poised to combat infection by responding rapidly to cytokine stimuli similar to innate lymphoid cells. This potential to initiate strong inflammatory responses necessitates that inhibitory si...

Turn-ons for axons

In This Issue In This Issue Nuclear proteins get around rotein trafficking between the cytoplasm and the nucleus has been studied extensively; but how do proteins move from one site to another within the nu-cleus? On page 615, Leung and Lamond focus on the intranuclear trafficking of the RNA-binding protein NHPX, and describe an elegant series of experiments that demonstrates the existence of m...

To the Framingham data, turn, turn, turn.

Recognition and Location of Power Transformer Turn to Turn Fault by Analysis of Winding Imposed Forces

Turn to turn fault is one of the major internal failures in the power transformers that if it is not quickly detected, can be extended and led to a complete transformer breakdown. So, the diagnosis and location of the turn to turn fault of the power transformer, as one of the most important equipment in the power system, is the main objective of this paper. For this purpose, a detailed model of...